Where 10.5" sits on the EN scale
EN ISO 21420 sizes are one inch of circumference apart, so a 10.5-inch hand sits halfway between sizes 10 and 11. Unisex work and sports gloves round it to 11 (XXL); makers that sell half sizes (dress leather, goalkeeper, surgical) make a 10.5.
Between two sizes, a tight-fitting glove (exam, golf, race) usually goes to 10, an insulated or lined one to 11.
10.5" × 25.4 = 267 mm round flat width ≈ 267 ÷ 2.42 = 110 mm (men)